COMPARISON OF DRUG SAFETY DATA OBTAINED FROM THE MONITORING SYSTEM, LITERATURE, AND SOCIAL MEDIA: AN EMPIRICAL PROOF FROM A CHINESE PATENT MEDICINE.

Comparison of drug safety data obtained from the monitoring system, literature, and social media: An empirical proof from a Chinese patent medicine.

OBJECTIVES:To investigate the consistency of adverse events (AEs) and adverse drug reactions (ADRs) reported in the literature, monitoring and social media data.METHODS:Using one Chinese patent medicine-Cordyceps sinensis extracts (CSE) as an example, we obtained safety data from the national monitoring system (July 2002 to February 2016), literatu

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Analysis of Informed Consent Forms Submitted to Institutional Ethics Committee of a Medical Institute in Southern India: A Cross-sectional Observational Study

Introduction: Informed consent is an essential component in research involving human participants.However, the informed consent obtained may be incomplete and not fulfill the essential criteria of Informed Consent Forms (ICFs).Although the guidelines for developing ICFs have been clearly spelled out by various research bodies, these guidelines are

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Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALSResearch in context

Background: Astrocytes regulate neuronal function, synaptic formation and maintenance partly through secreted extracellular vesicles (EVs).In amyotrophic lateral sclerosis (ALS) astrocytes display a toxic phenotype that contributes to motor neuron (MN) degeneration.Methods: We used human induced astrocytes (iAstrocytes) from 3 ALS patients carrying

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